Georgetown Database of Cancer (G-DOC)

Background:

The Georgetown Database of Cancer (G-DOC) is a novel, web-based platform that serves to enhance both basic and clinical research activities by hosting and integrating patient data with a variety of high-throughput biomedical research data types in a unified environment.  While a number of rich data repositories for high throughput research data exist in the public domain, many tend to focus on a single data type and do not support the integration across multiple technologies.  The integration of genomics and other biomedical patient data with clinical outcome data will enable physicians to tailor the most effective treatments to their patients (i.e. personalized medicine), while providing information about new drug targets to test in the laboratory. G-DOC contains biological and clinical data, including outcome information, for more than 3,300 breast cancer patients and more than 1,200 gastrointestinal cancer patients, all handled in a manner that enables maximum cross-comparability between studies. The application was released publicly released in April 2011. To acces the G-DOC please click here.

G-DOC is also re-architected as core and plug-in modules for other disease areas and re-branded as the Georgetown Clinical & Omics Development Engine (G-CODE). This new infrastructure will help to enable the widespread use of biomedical informatics tools by basic, clinical, and translational researchers in both cancer and non-cancer disease areas. The G-DOC/G-CODE platform provides powerful analytic tools and capabilities within easy-to-use interfaces, customized to the needs of each research community.

 Our Engagement:

As the prime contractor for G-DOC, ESAC, Inc. provides software engineering, requirements management and testing/quality assurance services for the construction of the platform. These include:

  • Architecture and design of the pluggable platform
  • Requirements management
  • Software engineering services
  • Integration with other applications like the caBIG® suite of tools as well as Pathway Studio ® and RedCap.
  • Documentation and user training
  • Outreach and presentations to the scientific community

Outcome:

ESAC, Inc. provided a one-stop-shop for all translational research platform development activities, as demonstrated by the success of the G-DOC platform. ESAC, Inc.’s service included the provision of subject matter expertise in omics data as well as providing novel ways of analyzing and presenting this data to physician researchers.

Other Projects:

ESAC's technical savvy and personable staff provides tremendous value to projects involving multi-center coordination and high dimensional data management. They merge a fundamental understanding of biology with expertise in data quality control and data security. Integrating all of these factors is key to delivering a secure and fast data portal for the scientific community.

Program Manager
NCI

We are quite impressed with not only by the technical skills provided by ESAC's software engineers but also by the depth and breadth of their subject matter experts who have provided guidance on standards and interoperability, quality assurance, and project management issues.

COTR
HHS/ONC

ESAC continues to be an exceptional collaborator providing on-site contractors with both the expertise for building new tools and data integration platforms, and the subject matter expertise in the biosciences needed to manage projects and provide significant added value beyond the technology development.

Director
Innovation Center for Biomedical Informatics at Georgetown University Medical Center

ESAC significantly improved the quality of bioinformatics applications of the NCI CBIIT program using industry best practices to ensure systems were validated both functionally and scientifically for use by the community.

Program Manager
NCI

Contact Us

Address

1801 Research Blvd.
Suite 500
Rockville, MD 20850
Location

Phone

(855) ESAC INC
(855) 372 2462

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