Research Data Management, Software Architecture and Development, Secure and High-Speed Data Sharing
The National Cancer Institute (NCI) has initiated a comprehensive analysis of the proteins expressed in cancer cells. This characterization of the cancer proteome complements earlier NCI efforts that described the cancer genome. ESAC, Inc. has been selected to engineer and manage the Data Coordinating Center and Data Portal that serves as the central repository for the proteomics data and distributes it to physicians, clinicians, and scientists in the cancer research community.
21st-century medicine involves the integration of data from many sources as researchers and physicians address diseases, like cancer, in a comprehensive fashion. In this project, our team is focused on the cancer proteome and our challenge is to receive large volumes of mass spectrometry data from research groups in the Clinical Proteomic Tumor Analysis Consortium (CPTAC). The proteomics data needs to be moved in a secure fashion, with no loss of content, and then these data must be made available to the public so that all researchers interested in the cancer proteome can access these data.
The proteomic data storage site previously used by the research community had problems with loss of data from files and slow times for data transfer.
ESAC, Inc. created a secure data portal for users by combining a web server with an Aspera, high-speed data transfer server.
Data is encrypted in transit and then verified by an md5 checksum
Daily transfer logs were developed to track and troubleshoot errors
The web site provides private areas for each research team to exchange data and also a shared area for the whole CPTAC program
ESAC's technical savvy and personable staff provides tremendous value to projects involving multi-center coordination and high dimensional data management. They merge a fundamental understanding of biology with expertise in data quality control and data security. Integrating all of these factors is key to delivering a secure and fast data portal for the scientific community.
Program Manager NCI
ESAC significantly improved the quality of bioinformatics applications of the NCI CBIIT program using industry best practices to ensure systems were validated both functionally and scientifically for use by the community.
Program Manager NCI
We are quite impressed with not only by the technical skills provided by ESAC's software engineers but also by the depth and breadth of their subject matter experts who have provided guidance on standards and interoperability, quality assurance, and project management issues.
ESAC continues to be an exceptional collaborator providing on-site contractors with both the expertise for building new tools and data integration platforms, and the subject matter expertise in the biosciences needed to manage projects and provide significant added value beyond the technology development.
Director Innovation Center for Biomedical Informatics at Georgetown University Medical Center
1801 Research Blvd.
Rockville, MD 20850 Location