Informatics Center for Cancer Family Registries


As the prime contractor for BCCFR Informatics Support Center, Georgetown University hosts a central data repository with data collected from a registry of 7 colon cancer and 6 breast cancer centers worldwide.  It maintains a web portal that allows investigators worldwide to request and obtain data various types of epidemiological data submitted by the Breast and Colon Cancer centers.

The original repository and web portal performance were subpar and ineffective, causing unacceptable delays in servicing requests for custom datasets.  Users would often have to wait an entire year to get their datasets created. Poor database design coupled with lack of adequate quality checks on the stored data led to a difficult submission process and unreliable data processing.

Our Engagement:

Following industry best practices and business process re-engineering techniques, ESAC, Inc. turned the situation around for the program by:

  • Redesigning the repository database for optimum storage and performance.
  • Developing an efficient step-wise data request and submission process, including systematic organization of extensive documentation (SOPs, Forms, DUAs, etc).
  • Developing and implementing a proprietary Quality Control Tool used to standardize data for all centers prior to submission to the repository.
  • Establishing a Quality Control methodology to ensure data provisions align with investigator needs.
  • Improving the web portal application to ensure enhanced user experience, in addition to using advanced business intelligence tools to integrate summary level data for analytics.
  • In collaboration with Georgetown University, published a case study on Informatics and Data Quality. This paper can be viewed at JAMIA website.


ESAC, Inc.’s technical and process expertise enabled the customer to eliminate a 14-month backlog of data requests within 2 months. A transparent, efficient and stakeholder-engaged process enabled the ESAC, Inc. team to turn around the situation and establish an efficient, customer focused informatics support center.

Other Projects:

ESAC continues to be an exceptional collaborator providing on-site contractors with both the expertise for building new tools and data integration platforms, and the subject matter expertise in the biosciences needed to manage projects and provide significant added value beyond the technology development.

Innovation Center for Biomedical Informatics at Georgetown University Medical Center

ESAC's technical savvy and personable staff provides tremendous value to projects involving multi-center coordination and high dimensional data management. They merge a fundamental understanding of biology with expertise in data quality control and data security. Integrating all of these factors is key to delivering a secure and fast data portal for the scientific community.

Program Manager

We are quite impressed with not only by the technical skills provided by ESAC's software engineers but also by the depth and breadth of their subject matter experts who have provided guidance on standards and interoperability, quality assurance, and project management issues.


ESAC significantly improved the quality of bioinformatics applications of the NCI CBIIT program using industry best practices to ensure systems were validated both functionally and scientifically for use by the community.

Program Manager

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1801 Research Blvd.
Suite 500
Rockville, MD 20850


(855) ESAC INC
(855) 372 2462

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