Quality Assurance for Biomedical Informatics Tools


The Center for Biomedical Informatics and Information Technology (CBIIT) helps speed scientific discovery and facilitates translational research by building many types of tools and resources that enable information to be shared along the continuum from the scientific bench to the clinical bedside and back.

CBIIT offers critical open-source infrastructure components that others can use to develop valuable databases and software tools to meet specific research needs. CBIIT’s expanding suite of tools is built from these foundational components including:

  • caArray – microarray data management system
  • caIntegrator – web-based software package that allows researchers to set up custom web portals for integrative research
  • National Biomedical Imaging Archive (NBIA) – searchable, national repository integrating in vivo cancer images with clinical and genomic data

Our Engagement:

ESAC, Inc. supported the mission of CBIIT by providing a team of Subject Matter Experts (SMEs) with extensive knowledge and experience in life sciences, bioinformatics and quality assurance. Our engagement at NCI included:

  • Validated algorithms by reproducing the results manually and comparing with the system output.
  • Researched and recommended the best methods for research based on latest bioinformatics literature and findings.
  • Provided Subject Matter Expertise ensure that the correct methods and parameters are used for the scientific analysis.
  • Curated clinical and genomic data for public availability through National Cancer Institute software tools.
  • Presented software tools in live demonstrations and at scientific meetings.
  • Performed manual and automated tests
  • Find, report, and track defects in software


Using industry best practices in Quality Assurance techniques, ESAC, Inc. has been able to provide an exponential increase in the quality and scientific validity of NCICB’s bioinformatics applications. Our Subject Matter Experts were able to provide scientific validation of the systems and databases including validation of algorithms, validation with latest bioinformatics literatures and appropriate methods were used for scientific analysis.

Other Projects:

ESAC continues to be an exceptional collaborator providing on-site contractors with both the expertise for building new tools and data integration platforms, and the subject matter expertise in the biosciences needed to manage projects and provide significant added value beyond the technology development.

Innovation Center for Biomedical Informatics at Georgetown University Medical Center

ESAC significantly improved the quality of bioinformatics applications of the NCI CBIIT program using industry best practices to ensure systems were validated both functionally and scientifically for use by the community.

Program Manager

ESAC's technical savvy and personable staff provides tremendous value to projects involving multi-center coordination and high dimensional data management. They merge a fundamental understanding of biology with expertise in data quality control and data security. Integrating all of these factors is key to delivering a secure and fast data portal for the scientific community.

Program Manager

We are quite impressed with not only by the technical skills provided by ESAC's software engineers but also by the depth and breadth of their subject matter experts who have provided guidance on standards and interoperability, quality assurance, and project management issues.


Contact Us


1801 Research Blvd.
Suite 500
Rockville, MD 20850


(855) ESAC INC
(855) 372 2462

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