ESAC, Inc. to support the National Cancer Institute’s Biospecimen Pre-analytical Variables (BPV) Program

September 18, 2017

The Biospecimen Pre-analytical Variables (BPV) Program is a National Cancer Institute-sponsored study to systematically assess the effects of biospecimen pre-analytical factors on the molecular profile of biospecimens. Several molecular profiling studies have been conducted on a biospecimen cohort that has been collected using standard operating procedures under a set of preanalytical variables including cold ischemic time (delay to formalin fixation), time in formalin, freezing methods, and storage temperatures and durations.

ESAC, Inc. has been awarded this contract to realize NCI’s goal of data sharing which is essential for expedited translation of research results into knowledge, products, and procedures to improve human health. ESAC, Inc. has diligently curated and harmonized these data originating from disparate sources – biospecimen repositories, research laboratories and sequencing centers and made them available through the National Center for Biotechnology Information’s (NCBI) database of Genotypes and Phenotypes (dbGaP) and Sequence Read Archive (SRA) for their dissemination to general research community.

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ESAC significantly improved the quality of bioinformatics applications of the NCI CBIIT program using industry best practices to ensure systems were validated both functionally and scientifically for use by the community.

Program Manager

ESAC's technical savvy and personable staff provides tremendous value to projects involving multi-center coordination and high dimensional data management. They merge a fundamental understanding of biology with expertise in data quality control and data security. Integrating all of these factors is key to delivering a secure and fast data portal for the scientific community.

Program Manager

We are quite impressed with not only by the technical skills provided by ESAC's software engineers but also by the depth and breadth of their subject matter experts who have provided guidance on standards and interoperability, quality assurance, and project management issues.


ESAC continues to be an exceptional collaborator providing on-site contractors with both the expertise for building new tools and data integration platforms, and the subject matter expertise in the biosciences needed to manage projects and provide significant added value beyond the technology development.

Innovation Center for Biomedical Informatics at Georgetown University Medical Center

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